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Clinical trials for Drug resistant epilepsy

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
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    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    29 result(s) found for: Drug resistant epilepsy. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2020-004511-27 Sponsor Protocol Number: S64647 Start Date*: 2021-08-05
    Sponsor Name:University Hospital Leuven
    Full Title: Add-on clioquinol in drug-resistant childhood epilepsy: an exploratory study
    Medical condition: Drug resistant epilepsy in children
    Disease: Version SOC Term Classification Code Term Level
    21.0 10029205 - Nervous system disorders 10015037 Epilepsy PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-003241-26 Sponsor Protocol Number: EP0093 Start Date*: 2018-09-04
    Sponsor Name:UCB Biopharma SPRL
    Full Title: An Open-Label, Multicenter, Extension Study to Evaluate the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-Onset Seizures in Adult Subjects with Drug-Resistant Epilepsy
    Medical condition: Focal-Onset Seizures
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10065337 Focal epilepsy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) DE (Prematurely Ended) HU (Prematurely Ended) ES (Prematurely Ended) CZ (Completed) BG (Completed) FR (Completed) LT (Completed) BE (Completed) PT (Prematurely Ended) EE (Completed) NL (Completed) DK (Completed) AT (Completed) GR (Completed) FI (Completed) NO (Completed) SE (Completed) HR (Completed) IT (Completed) RO (Completed)
    Trial results: View results
    EudraCT Number: 2020-005954-78 Sponsor Protocol Number: 100-059 Start Date*: 2021-10-13
    Sponsor Name:CEA
    Full Title: Exploring P-glycoprotein-mediated efflux transport at the blood-brain barrier as a biomarker of drug-resistance in focal epilepsy
    Medical condition: Investigation in healthy volunteers and epilepsy patients
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2011-004156-19 Sponsor Protocol Number: VX11-765-402 Start Date*: 2012-06-21
    Sponsor Name:Vertex Pharmaceuticals Incorporated
    Full Title: A Phase 2b, Randomized, Double Blind, Placebo Controlled, Parallel Group, Dose Ranging Study to Evaluate the Efficacy and Safety of VX-765 in Subjects With Treatment Resistant Partial Epilepsy With...
    Medical condition: Partial epilepsy
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004852 10065336 Partial epilepsy LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) AT (Prematurely Ended) HU (Completed) GB (Prematurely Ended) FI (Completed)
    Trial results: View results
    EudraCT Number: 2011-005433-39 Sponsor Protocol Number: ADFNLE Start Date*: 2012-03-22
    Sponsor Name:AZIENDA OSPEDALIERO UNIVERSITARIA DI CAGLIARI
    Full Title: PHASE II OPEN STUDY ABOUT THE EFFECTIVENESS OF FENOFIBRATE AS ADD ON THERAPY FOR DRUG RESISTANT NOCTURNAL FRONTAL LOBE EPILEPSY (FNLE) .
    Medical condition: Drug resistant nocturnal frontal lobe epilepsy
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029205 - Nervous system disorders 10049424 Frontal lobe epilepsy PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-001268-20 Sponsor Protocol Number: EP0073 Start Date*: 2015-08-13
    Sponsor Name:UCB Biopharma SRL
    Full Title: AN OPEN-LABEL, MULTICENTER, EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY, TOLERABILITY, AND EFFICACY OF UCB0942 WHEN USED AS ADJUNCTIVE THERAPY FOR PARTIAL-ONSET SEIZURES IN ADULT SUBJECTS WITH...
    Medical condition: highly drug-resistant focal epilepsy
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004852 10065337 Focal epilepsy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) DE (Completed) BE (Completed) BG (Completed) HU (Completed) ES (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2017-003381-27 Sponsor Protocol Number: 100045 Start Date*: 2018-09-24
    Sponsor Name:CEA
    Full Title: Study in 18F-DPA714 PET to better locate preoperatively the epileptic focus to resect in drug-resistant partial epilepsy
    Medical condition: Brain imaging on people with partial pharmaco resistant epilepsy
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2014-003003-30 Sponsor Protocol Number: 2014-853 Start Date*: 2014-10-31
    Sponsor Name:HOSPICES CIVILS DE LYON
    Full Title: ENALEPSIE EFFICACY OF NALOXONE IN REDUCING POSTICTAL CENTRAL RESPIRATORY DYSFUNCTION IN PATIENTS WITH EPILEPSY.
    Medical condition: Sudden unexpected death in epilepsy (SUDEP) primarily affects young adults with drug-resistant epilepsy
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004852 10065336 Partial epilepsy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-006702-78 Sponsor Protocol Number: BraimTOR-NEURO Start Date*: Information not available in EudraCT
    Sponsor Name:The Children's Memorial Health Institute
    Full Title: Open, randomized, IInd phase clinical study evaluating the safety and efficacy of rapamycin in the treatment of drug-resistant epilepsy in children with rare and ultra-rare diseases of the central ...
    Medical condition: epilepsy, mTORopathies, focal cortical dysplasia, LEATS
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: PL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2018-002303-33 Sponsor Protocol Number: EP0092 Start Date*: 2019-01-03
    Sponsor Name:UCB Biopharma SPRL
    Full Title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-Onset Seizures in Adult Subjects...
    Medical condition: Focal-Onset Seizures
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10065337 Focal epilepsy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: EE (Completed) DE (Prematurely Ended) BE (Completed) GB (Completed) HU (Completed) NL (Completed) DK (Completed) SE (Completed) AT (Completed) GR (Completed) BG (Completed) FI (Completed) ES (Prematurely Ended) CZ (Completed) HR (Completed) FR (Completed) PT (Completed) SK (Prematurely Ended) IT (Prematurely Ended) RO (Completed)
    Trial results: View results
    EudraCT Number: 2017-003200-48 Sponsor Protocol Number: EP0091 Start Date*: 2018-04-09
    Sponsor Name:UCB Biopharma SPRL
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Dose Finding Study to Evaluate the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-Onset Seizures in Adult Subjects with Drug- Res...
    Medical condition: Focal-Onset Seizures
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10065337 Focal epilepsy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) HU (Completed) CZ (Completed) BE (Completed) ES (Completed) FR (Completed) BG (Completed) LT (Completed) SK (Completed) PT (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2018-003464-32 Sponsor Protocol Number: VNS-MIR2018 Start Date*: 2019-11-05
    Sponsor Name:
    Full Title: Effect of mirtazapine on seizure frequency in medically refractory epileptic patients with vagal nerve stimulation
    Medical condition: epilepsy
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-003330-12 Sponsor Protocol Number: EP0069 Start Date*: 2015-08-18
    Sponsor Name:UCB Biopharma SPRL
    Full Title: A double-blind, randomized, placebo-controlled study of the efficacy, safety/tolerability, and pharmacokinetic profile of UCB0942 in adult patients with highly drug-resistant focal epilepsy
    Medical condition: highly drug-resistant focal epilepsy
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004852 10065337 Focal epilepsy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) BE (Completed) NL (Completed) HU (Completed) ES (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2019-003137-42 Sponsor Protocol Number: EPIFLUX Start Date*: 2020-04-10
    Sponsor Name:Medizinische Universität Wien, Universitätsklinik für Klinische Pharmakologie
    Full Title: Exploring P-glycoprotein-mediated efflux transport at the blood-brain barrier as a biomarker of drug-resistance in focal epilepsy
    Medical condition: Investigation in healthy volunteers and epilepsy patients
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-004008-46 Sponsor Protocol Number: FFA-LGS Start Date*: 2016-01-07
    Sponsor Name:UZ Leuven
    Full Title: Add-on fenfluramine in Lennox Gastaut epilepsy
    Medical condition: Lennox Gastaut Epilepsy
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2014-004363-21 Sponsor Protocol Number: 1042-0603 Start Date*: 2015-03-11
    Sponsor Name:Marinus Pharmaceuticals, Inc
    Full Title: A Multicenter, Double Blind, Randomized, Placebo-Controlled Trial to Determine the Efficacy and Safety of Ganaxolone as Adjunctive Therapy for Adults with Drug-Resistant Partial-Onset Seizures Foll...
    Medical condition: Drug-Resistant Epilepsy with Partial-Onset Seizures
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004852 10065336 Partial epilepsy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Prematurely Ended) DE (Prematurely Ended) PL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2021-004548-64 Sponsor Protocol Number: RaRETS Start Date*: Information not available in EudraCT
    Sponsor Name:The Children's Memorial Health Institute
    Full Title: Multicenter, randomized, double-blind, placebo controlled study to assess the efficacy and safety of Rapamycin in drug Resistant Epilepsy associated with TSC (RaRE-TS)
    Medical condition: tuberous sclerosis complex, epilepsy, organ tumors associated with tuberous sclerosis
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: PL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-002147-15 Sponsor Protocol Number: 200200 Start Date*: Information not available in EudraCT
    Sponsor Name:AZIENDA SOCIO SANITARIA TERRITORIALE DI MANTOVA
    Full Title: Intravenous immunoglobulin for Unverricht–Lundborg disease: single-patient trial.
    Medical condition: Unverricht-Lundborg disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10010331 - Congenital, familial and genetic disorders 10054858 Unverricht's syndrome LLT
    20.0 10010331 - Congenital, familial and genetic disorders 10054895 Baltic myoclonic epilepsy PT
    20.0 10010331 - Congenital, familial and genetic disorders 10054894 Unverricht-Lundborg disease LLT
    Population Age: Adults Gender: Male
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-005528-40 Sponsor Protocol Number: EPISTOP Start Date*: 2014-12-05
    Sponsor Name:The Children's Memorial Health Institute
    Full Title: Long-term, prospective study evaluating clinical and molecular biomarkers of epileptogenesis in a genetic model of epilepsy – Tuberous Sclerosis Complex.
    Medical condition: Epilepsy in tuberous sclerosis complex (TSC)
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004852 10032061 Other forms of epilepsy LLT
    Population Age: Newborns, Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed) BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-001019-35 Sponsor Protocol Number: D16-P15 Start Date*: 2017-12-19
    Sponsor Name:Centre Hospitalier Sainte-Anne
    Full Title: Effect of vitamin D deficiency compensation in the treatment of drug-resistant epilepsy.
    Medical condition: Patients suffering from drug-resistant epilepsy.
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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