Flag of the European Union EU Clinical Trials Register Help

Clinical trials for Lower gastrointestinal tract

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    58 result(s) found for: Lower gastrointestinal tract. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2007-004127-38 Sponsor Protocol Number: TILATT/0708 Start Date*: 2008-06-17
    Sponsor Name:AZIENDA OSPEDALIERA OSPEDALE POLICLINICO CONSORZIALE
    Full Title: USE OF ORAL TILACTASE ENZYMES IN SUBJECTS WITH LACTOSE MALABSORPTION AND INTOLERANCE. CLINICAL RELEVANCE IN A POPULATION WITH HIGH PREVALENCE OF LACTASE DEFICIENCY IN SOUTHERN ITALY.
    Medical condition: primary lactase deficiency
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10017947 Gastrointestinal disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-002418-22 Sponsor Protocol Number: T-016 Start Date*: 2014-11-07
    Sponsor Name:Trio Medicines Ltd
    Full Title: Randomized, placebo-controlled trial of YF476, a gastrin receptor antagonist, in Barrett’s esophagus (10-505; T-016)
    Medical condition: Barrett's oesophagus
    Disease: Version SOC Term Classification Code Term Level
    18.0 10017947 - Gastrointestinal disorders 10004137 Barrett's oesophagus PT
    18.0 10017947 - Gastrointestinal disorders 10052778 Gastrointestinal mucosal dystrophies and secretion disorders HLT
    18.0 10017947 - Gastrointestinal disorders 10017943 Gastrointestinal conditions NEC HLGT
    18.0 10017947 - Gastrointestinal disorders 10017947 Gastrointestinal disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-001097-24 Sponsor Protocol Number: PHT/2013/01 Start Date*: 2013-05-23
    Sponsor Name:Portsmouth Hospitals NHS trust
    Full Title: Use of N-Acetylcysteine (NAC) and Simeticone as a pre-endoscopic drink to improve mucosal visualisation during gastroscopy: A randomised controlled trial
    Medical condition: Early gastrointestinal lesions in the upper gastrointestinal tract. Our study is not looking at the direct treatment of any particular condition, but the early detecton of lesions. When performin...
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022891 - Investigations 10014809 Endoscopy gastrointestinal PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-003637-14 Sponsor Protocol Number: AGO/2018/004 Start Date*: 2019-03-29
    Sponsor Name:Ghent University Hospital
    Full Title: Local injection of collagenase clostridium histolyticum (XiapexR) for refractory gastrointestinal strictures: an open-label pilot study.
    Medical condition: refractory iatrogenic gastrointestinal strictures
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004863 10078825 Gastrointestinal anastomotic stricture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2016-001684-36 Sponsor Protocol Number: GED0507-UC-001 Start Date*: 2016-12-12
    Sponsor Name:PPM SERVICES SA
    Full Title: A PHASE 2, RANDOMIZED, PLACEBO-CONTROLLED, MULTICENTER STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF GED-0507-34-LEVO (GED0507) FOR TREATMENT OF SUBJECTS WITH ACTIVE ULCERATIVE COLITIS
    Medical condition: Ulcerative Colitis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10017947 - Gastrointestinal disorders 10021184 IBD LLT
    20.0 10017947 - Gastrointestinal disorders 10045365 Ulcerative colitis LLT
    20.0 10017947 - Gastrointestinal disorders 10045366 Ulcerative colitis, unspecified LLT
    20.0 10017947 - Gastrointestinal disorders 10017947 Gastrointestinal disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SK (Prematurely Ended) HU (Prematurely Ended) BG (Prematurely Ended) LV (Prematurely Ended) ES (Prematurely Ended) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-002624-28 Sponsor Protocol Number: FIT-EU-04 Start Date*: 2015-09-24
    Sponsor Name:Nutrinia Ltd.
    Full Title: A Multi-center, Double-blind, Randomized Placebo Controlled Study to Assess the Efficacy and Safety of NTRA-2112 on Gastrointestinal Maturation in Preterm Infants.
    Medical condition: Gastrointestinal Maturation in Preterm Infants.
    Disease:
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: ES (Prematurely Ended) BE (Completed) NL (Prematurely Ended) GB (Prematurely Ended) HU (Prematurely Ended) DE (Prematurely Ended) BG (Prematurely Ended) FR (Prematurely Ended) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2021-004588-29 Sponsor Protocol Number: TA799-101 Start Date*: 2022-02-01
    Sponsor Name:VectivBio AG
    Full Title: A randomized, single-blind trial to evaluate the safety and efficacy of apraglutide in subjects with Grade II to IV (MAGIC) steroid refractory gastrointestinal (GI) acute graft versus host disease ...
    Medical condition: Acute graft versus host disease (aGVHD)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021428 - Immune system disorders 10075160 Graft versus host disease in gastrointestinal tract PT
    20.0 10021428 - Immune system disorders 10075161 Graft versus host disease in GI tract LLT
    20.1 10021428 - Immune system disorders 10066264 Acute graft versus host disease in intestine PT
    20.1 10021428 - Immune system disorders 10066260 Acute graft versus host disease PT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Trial now transitioned) ES (Ongoing) PT (Prematurely Ended) FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-014845-95 Sponsor Protocol Number: NRL0706-01/2009 (VOM) Start Date*: 2010-02-22
    Sponsor Name:Norgine Ltd.
    Full Title: Open study to assess the tolerability, safety and efficacy of an adapted 2 litre gut cleansing solution (NRL0706) in routine colon cleansing prior to colonoscopies for colon tumour screening
    Medical condition: Subjects without relevant clinical symptoms for gastrointestinal disorders will undergo a complete selective colonoscopy for colon cancer screening.
    Disease: Version SOC Term Classification Code Term Level
    12.0 10010007 Colonoscopy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2008-008857-53 Sponsor Protocol Number: DC10004 Start Date*: 2009-02-25
    Sponsor Name:Acacia Pharma Ltd
    Full Title: Open-Label, Pilot Phase I/II Study of the Efficacy and Safety of Concomitant Megestrol + Formoterol in Patients with Cachexia and Advanced Malignancy
    Medical condition: Cancer-related cachexia, also known as Cancer Anorexia-Cachexia Syndrome (CACS)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10064015 Cancer cachexia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2016-002302-39 Sponsor Protocol Number: RSV-M-301 Start Date*: 2016-09-06
    Sponsor Name:Novavax, Inc.
    Full Title: A Phase 3, Randomized, Observer-Blind, Placebo-Controlled, Group-Sequential Study to Determine the Immunogenicity and Safety of a Respiratory Syncytial Virus (RSV) F Nanoparticle Vaccine with Alumi...
    Medical condition: Respiratory syncytial virus (RSV) is the leading viral cause of severe lower respiratory tract disease in infants and young children worldwide. In industrialized countries, nearly all children have...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10061603 Respiratory syncytial virus infection PT
    Population Age: In utero, Newborns, Infants and toddlers, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (Completed) ES (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2010-021879-85 Sponsor Protocol Number: 10050 Start Date*: 2010-09-08
    Sponsor Name:University of Nottingham
    Full Title: Mode of action of Moviprep:impact on distribution of intestinal fluid and colonic microbiota
    Medical condition: for bowel cleansing prior to any clinical procedure requiring a clean bowel, e.g, bowel endoscopy, lower gastrointestinal tract radiology or digestive tract surgery.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2021-001841-11 Sponsor Protocol Number: MPOH06 Start Date*: 2021-11-09
    Sponsor Name:MaaT Pharma
    Full Title: Evaluation of the efficacy of MaaT013 as salvage therapy in acute GVHD patients with gastrointestinal involvement, refractory to ruxolitinib; a multi-center open-label phase III trial
    Medical condition: Salvage therapy of acute GVHD patients with gastrointestinal involvement, refractory to ruxolitinib.
    Disease: Version SOC Term Classification Code Term Level
    20.1 10021428 - Immune system disorders 10066264 Acute graft versus host disease in intestine PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned) ES (Ongoing) AT (Trial now transitioned) BE (Trial now transitioned) IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2011-005688-26 Sponsor Protocol Number: Abstral Start Date*: 2012-02-01
    Sponsor Name:Turku University Hospital
    Full Title: Procedural pain treatment with transmucosal sublingual fentanyl tablet in colonoscopy patients
    Medical condition: Patients undergoing colonoscopy
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022891 - Investigations 10010007 Colonoscopy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-001749-15 Sponsor Protocol Number: ARC005 Start Date*: 2019-05-21
    Sponsor Name:Aimmune Therapeutics , Inc.
    Full Title: Peanut Oral Immunotherapy Study of Early Intervention for Desensitization (POSEIDON)
    Medical condition: Peanut Allergy
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004870 10034202 Peanut allergy LLT
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) IE (Completed) FR (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2007-005547-17 Sponsor Protocol Number: RHMNUT0048 Start Date*: 2010-01-28
    Sponsor Name:Southampton University Hospital NHS Trust
    Full Title: Refeeding risks in patients requiring nutrition support. A twin centre double-blind randomised controlled trial of parenteral nutrition support.
    Medical condition: Patients who have a non-functioning gastrointestinal tract require artifical intravenous nutrition. This is usally a result recent surgery or sepsis causing a reversible short term paralysis of th...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2017-001976-48 Sponsor Protocol Number: IM011023 Start Date*: 2018-08-23
    Sponsor Name:Bristol-Myers Squibb International Corporation
    Full Title: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of BMS-986165 in Subjects with Moderate to Severe Crohn's Disease
    Medical condition: Crohn's Disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10017947 - Gastrointestinal disorders 10011401 Crohn's disease PT
    20.0 10017947 - Gastrointestinal disorders 10011398 Crohn's LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) HU (Completed) FR (Completed) ES (Ongoing) PL (Completed) DE (Completed) DK (Prematurely Ended) PT (Completed) NL (Completed) BE (Completed) IT (Completed) RO (Ongoing)
    Trial results: View results
    EudraCT Number: 2016-004217-26 Sponsor Protocol Number: CSUC-01/16 Start Date*: 2017-04-21
    Sponsor Name:InDex Pharmaceuticals AB
    Full Title: A Randomised Dose-Optimisation Study to Evaluate the Efficacy and Safety of Cobitolimod in Moderate to Severe Active Ulcerative Colitis Patients
    Medical condition: Moderate to Severe left-sided Active Ulcerative Colitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) HU (Completed) SE (Completed) ES (Completed) CZ (Completed) FR (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2018-000326-58 Sponsor Protocol Number: ARC009 Start Date*: 2018-09-27
    Sponsor Name:Aimmune Therapeutics, Inc.
    Full Title: Peanut Allergy Oral Immunotherapy Study of AR101 for Desensitization in Children and Adolescents: Real-World, Open-Label, Quality of Life Study
    Medical condition: Peanut Allergy
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021428 - Immune system disorders 10016946 Food allergy PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) IE (Prematurely Ended) SE (Prematurely Ended) ES (Prematurely Ended) FR (Prematurely Ended) DE (Prematurely Ended) NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-004581-14 Sponsor Protocol Number: A3921139 Start Date*: 2012-06-29
    Sponsor Name:Pfizer Inc.
    Full Title: A MULTI-CENTER, OPEN-LABEL STUDY OF CP-690,550 IN SUBJECTS WITH MODERATE TO SEVERE ULCERATIVE COLITIS
    Medical condition: Ulcerative colitis
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004856 10045365 Ulcerative colitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) DK (Completed) HU (Completed) EE (Completed) GB (Completed) LV (Completed) BE (Completed) NL (Completed) ES (Completed) AT (Completed) DE (Completed) SK (Completed) PL (Completed) IT (Completed) HR (Completed)
    Trial results: View results
    EudraCT Number: 2007-005575-34 Sponsor Protocol Number: P060240 Start Date*: 2008-02-08
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
    Full Title: Comparaison de la tolérance et de l'acceptabilité de la coloscopie sous sédation par mélange équimolaire d'oxygène et de protoxyde d'azote par rapport à l'anesthésie générale : Etude randomisée mul...
    Medical condition: maladies digestives.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10010007 PT
    Population Age: Adults, Elderly Gender:
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    1  2  3  Next»
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-Sun May 11 23:32:21 CEST 2025 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA